One Size Doesn't Fit All
Pharmacogenomics is a study of how genes affect a person's response to a drug, thereby using a patient's genetic profile to predict a drugs efficacy, guide dosage and improve safety.
You receive thousands of genes from your parents which determine the characteristics of your body. Some of the genes are responsible for how your body processes medications. Pharmacogenomic tests look for the variants in these genes to check whether a medication could be effective or not for you. Thus a medication may work well for some and may not be a good fit for others due to their genetic differences.
Comprehensive medication management incorporating pharmacogenomics focuses on customizing pharmacotherapy to each individual. It considers not only the DNA information but also lifestyle, age, and other medications you are taking to decide on the right treatment for you.
Facts
* Adverse drug reactions are the 4th leading cause of death in US. It's ahead of pulmonary disease, diabetes, AIDs, pneumonia, and automobile accidents.
* About 400 FDA approved medications have drug-gene interactions.
* Over 60% of people are prescribed at least one medication that has a drug-gene interaction.
* 12% of people take four or more medications that the FDA requires or recommends DNA testing.
* 95% of the population are estimated to carry at least one genetic variant that is at odds with at least one medication.
Predicting a patient's response to medications could support the safe management of medications and reduce hospitalization.
These benefits can only be realized if clinicians make medication changes prompted by PGx test results
Benefits of Parmacogenomics
Improve your health and quality of life by:
* Decreasing drug related side effects.
* Decreasing drug therapy failures.
* Decreasing doctor visits.
* Decreasing hospitalizations and ER visits.
* Decreasing number of medications needed.
* Decreasing disease progression.
Help you to know ahead whether a medication is right for you.
Help guide physicians to prescribe the most effective medications with less side effects.
You only need to test once and it will provide medication guidance for life.
References
https://www.mayo.edu/research/centers-programs/center-individualized-medicine/patient-care/pharmacogenomics
David V, Fylan B, Bryant E, Smith H, Sagoo GS, Rattray M. An Analysis of Pharmacogenomic-Guided Pathways and Their Effect on Medication Changes and Hospital Admissions: A Systematic Review and Meta-Analysis. Front Genet. 2021 Jul 30;12:698148. doi: 10.3389/fgene.2021.698148. PMID: 34394187; PMCID: PMC8362615.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563578/
https://pubmed.ncbi.nlm.nih.gov/34064668/
https://medlineplus.gov/genetics/understanding/precisionmedicine/definition/
https://www.mayoclinic.org/healthy-lifestyle/consumer-health/in-depth/personalized-medicine/art-20044300
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696803/
https://www.fda.gov/drugs/science-and-research-drugs/table-pharmacogenomic-biomarkers-drug-labeling
https://www.mlo-online.com/continuing-education/article/13009247/the-role-of-pharmacogenomics-in-precision-medicine
https://blog.cureatr.com/the-difference-between-medication-therapy-management-and-comprehensive-medication-management
https://www.fda.gov/drugs/drug-interactions-labeling/preventable-adverse-drug-reactions-focus-drug-interactions
https://pubmed.ncbi.nlm.nih.gov/33806453/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051925/
https://pubmed.ncbi.nlm.nih.gov/25987241/
https://youscript.com/new-precision-medicine-study-confirms-dramatic-reduction-in-readmissions-and-er-visits-in-polypharmacy-home-health-care-patients/
https://pubmed.ncbi.nlm.nih.gov/32015062/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920773/
https://www.cdc.gov/genomics/disease/pharma.htm